Fig. 4

Nrf2 pathway was responsible for UA-induced repression of CMT process in CFs with TGF-β1 treatment. A The mRNA level and B the protein level of fibrosis markers including vimentin, DDR2, tensin and α-SMA in CFs after indicated treatments. C The protein levels of Nrf2, SOD1, HO-1 and NQO1 in CFs after indicated treatments. β-actin was used as normalized control. NC: negative control. N = 3, *P < 0.05, **P < 0.01, ***P < 0.001