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Fig. 4 | Molecular Medicine

Fig. 4

From: Gut bacterial metabolite Urolithin A inhibits myocardial fibrosis through activation of Nrf2 pathway in vitro and in vivo

Fig. 4

Nrf2 pathway was responsible for UA-induced repression of CMT process in CFs with TGF-β1 treatment. A The mRNA level and B the protein level of fibrosis markers including vimentin, DDR2, tensin and α-SMA in CFs after indicated treatments. C The protein levels of Nrf2, SOD1, HO-1 and NQO1 in CFs after indicated treatments. β-actin was used as normalized control. NC: negative control. N = 3, *P < 0.05, **P < 0.01, ***P < 0.001

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