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Fig. 3 | Molecular Medicine

Fig. 3

From: Increased plasmablasts enhance T cell-mediated beta cell destruction and promote the development of type 1 diabetes

Fig. 3

Plasmablasts in T1D retain the antigen-presenting feature. A Representative histograms of HLA-II, CD86, CD80, and CD40 expression on B cell subsets from patients with new-onset T1D. BE The analyses of the HLA-II, CD86, CD80, and CD40 expression on B cell subsets. Data indicate mean ± SEM. Difference between groups were assessed by One-way ANOVA followed by Dunnett's multiple comparisons test. ** P < 0.01 compared with naïve B cells. FG Comparison of the HLA-II+ and CD86+ plasmablast frequencies in B cell compartment between control subjects and patients with new-onset T1D. Data indicate mean ± SEM. Independent t test, * P < 0.05. H Association between CD86 expression and FCP and 2hCP in patients with new-onset T1D. I Association between CD86 expression on plasmablasts and IFN-γ+CD4+ T cells in patients with new-onset T1D. Correlation was assessed by Pearson analysis. FCP, plasma fasting C-peptide; 2hCP, plasma 2-h postprandial C-peptide

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