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Table 1 Characteristics of participants

From: Increased plasmablasts enhance T cell-mediated beta cell destruction and promote the development of type 1 diabetes

 

CON (n = 26)

NO-T1D (n = 36)

LT-T1D (n = 20)

T2D (n = 22)

P value

Gender, Men (n)

Age (years)

22.2 ± 9.3

26.1 ± 14.2

27.9 ± 15.3

47.3 ± 12.2a,b,c

 < 0.001

  < 18 years, n (%)

10 (38)

12 (33)

6 (30)

0 (0)

 

  ≥ 18 years, n (%)

16 (62)

24 (67)

14 (70)

22 (100)

 

Onset-age (years)

/

26.1 ± 14.3

24.0 ± 15.6

47.1 ± 12.8b,c

 < 0.001

Duration (months)

/

2.0 ± 2.1

45.8 ± 23.5

1.3 ± 1.3c

 < 0.001

BMI (kg/m2)

20.8 ± 2.5

19.5 ± 3.0

20.6 ± 3.3

24.0 ± 2.5a,b,c

 < 0.001

DK or DKA (%)

0.0

75.0

55.0

9.1

 < 0.001

Family History of Diabetes (%)

30.8

25.0

15.0

54.5

0.033

HbA1c (mmol/mol)

34 ± 3.3

84 ± 31.7

65 ± 26.2

96 ± 31.7

 

HbA1c (%)

5.3 ± 0.3

9.8 ± 2.9a

8.1 ± 2.4 a

10.9 ± 2.9a,c

 < 0.001

FPG (mmol/l)

4.3 ± 0.5

7.4 ± 2.8a

10.1 ± 4.8 a,b

9.5 ± 3.4a,b

 < 0.001

2hPG (mmol/l)

4.5 ± 1.3

13.5 ± 4.6a

13.3 ± 3.6 a

15.8 ± 3.6a

 < 0.001

FCP (pmol/l)

558.4 (489.2, 719.0)

226.0 (141.4, 323.2)a

32.3 (9.8, 242.3)a

520.4 (348.5, 789.1)b,c

 < 0.001

2hCP (pmol/l)

1717 (1321.0, 2261.0)

425.5 (243.2, 795.8)a

82.9 (16.5, 387.0)a

964.9 (747.61782.0)b,c

 < 0.001

IAA+

0

2

3

0

 

ICA+

0

22

5

0

 

GADA+

0

34

13

0

 

IA2A+

0

24

8

0

 

No. of autoantibodies

 4

 

1

1

  

 3

 

15

1

  

 2

 

13

8

  

 1

 

7

5

  
  1. Data are n, %, mean ± SD, and median (25th–75th percentile). /, not appropriate. aP < 0.05 vs CON; bP < 0.05 vs NO-T1D; cP < 0.05 vs LT-T1D; NO-T1D, new-onset T1D; LT-T1D, long-term T1D; T2D, type 2 diabetes; FPG, fasting plasma glucose; 2hPG, 2 h postprandial plasma glucose; FCP, fasting C-peptide; 2hCP, 2-h postprandial C-peptide; DK, diabetic ketosis; DKA, diabetic ketoacidosis