Fig. 9
From: Lansoprazole-induced osteoporosis via the IP3R- and SOCE-mediated calcium signaling pathways
Patch clamp recording of currents. A The recorded current was determined to be NCX. B Initial induced current of NCX and the effect of different lansoprazole concentrations and Ni2+ on INCX; gray: 5 mM NiCl2; brown: 0 µM lansoprazole; blue: 10 µM lansoprazole; black: 50 µM lansoprazole; red: 100 µM lansoprazole. C NCX current peak statistics of MC3T3-E1 cells in response to different lansoprazole concentrations; forward current density peak statistics, #P < 0.05 vs. the normal group; reverse current density peak statistics, *P < 0.05 vs. the normal group, **P < 0.01 vs. normal group. (x + s, n = 6)