Fig. 6

Clearance of circulating Ox-LDL by ectopic expression of LOX-1 in the liver significantly reduce migration of macrophages in plaques and VCAM-1 expression in vascular endothelium. A–C Representative images of the co-localization of MCP-1 and CD68 in the plaque obtained from the control and LOX-1 groups by using immunofluorescence (A). DAPI were used to stain nuclei (blue). The percentage of MCP-1/CD68 is presented among the indicated groups (B). The percentage of the plaque area that was occupied by CD68 is presented among the indicated groups (C). D, E Representative images of the plaque in the control and LOX-1 groups stained with VCAM-1 (D). DAPI were used to stain nuclei (blue). The percentage of the aortic root area that was occupied by VCAM-1 is presented among the indicated groups (E). Values are expressed as mean ± SD (n = 7). **P < 0.01 compared with the control group