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Fig. 1 | Molecular Medicine

Fig. 1

From: Molecular landscape of IDH-mutant astrocytoma and oligodendroglioma grade 2 indicate tumor purity as an underlying genomic factor

Fig. 1

Somatic mutation landscape of IDH-mt astrocytoma and grade 2oligodendroglioma. A Somatic mutations in astrocytoma + oligodendroglioma (n = 223). B Somatic mutations in astrocytoma (n = 130). C Somatic mutations in oligodendroglioma (n = 93). D Somatic mutation frequency of genes in key pathways of astrocytoma. E Somatic mutation frequency of genes in key pathways of oligodendroglioma. Each column represents an individual patient. The number on the left indicates the mutation frequency, with a bar plot showing the proportion of each variant type. Gene names are indicated on the right. F COSMIC mutation signatures in astrocytoma + oligodendroglioma (n = 166) by APOBEC1, C > T CpG, dMMR and unknown groups. G. TMB value between astrocytoma and oligodendroglioma (Wilcoxon p = 0.81). H Proportion of mutated and wild type ATRX, TERT, TP53, PTEN, and PIK3CA genes between astrocytoma and oligodendroglioma (*Chi-square test p < 0.05; ***p < 0.001). TMB tumor mutation burden

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Molecular Medicine

ISSN: 1528-3658