Fig. 2

Copy number alterations and DNA damage repair-related signatures. A Genomic overview showing the percentage of samples with CNA in astrocytoma, oligodendroglioma and astrocytoma + oligodendroglioma. Some landmark genes and their locations are depicted. B Proportion of amplification and deletion of key genes/driver genes between astrocytoma and oligodendroglioma. C Rankings of CNA frequency referring to gain and loss status in astrocytoma + oligodendroglioma. D Number of CNAs between astrocytoma and oligodendroglioma (Wilcoxon P < 2.22e−16). E MSI between astrocytoma and oligodendroglioma (P = 0.900). F Quantification of DDR-related signatures in astrocytoma and oligodendroglioma (Wilcoxon rank-sum test). G Correlation between DDR-related pathways and tumor purity in astrocytoma. H Correlation between DDR-related pathways and tumor purity in oligodendroglioma. Pearson’s correlation analyses were conducted between tumor purity of astrocytoma/oligodendroglioma and each DDR-related pathway, and among the pathways. The coefficients were reported respectively. CNA copy number alternation, AS aneuploidy score, DDR DNA damage repair, SGF subclonal genome fraction, LOH loss-of-heterozygosity, HRD homologous recombination defect, PARPi poly (ADP-ribose) polymerase inhibitors, BER base excision repair, NER nucleotide excision repair, MMR mismatch repair, FA Fanconi anemia, HR homologous recombination, NHEJ nonhomologous end joining, DR direct repair, TLS translesion synthesis, DS damage sensor