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Fig. 4 | Molecular Medicine

Fig. 4

From: Gene therapy of yeast NDI1 on mitochondrial complex I dysfunction in rotenone-induced Parkinson’s disease models in vitro and vivo

Fig. 4

The mitochondrial ROS level and mitochondria-mediated apoptosis level in rotenone-induced PD cell model transduced with NDI1. A The ROS level in mitochondria was examined by MitoSOX™ staining. B The mitochondria-mediated apoptosis level was examined by western blot using cleaved caspase-9 antibody and cleaved caspase-3 antibody with β-actin as loading control. MFI: median fluorescence intensity. Rotenone + vector group compared with DMSO + vector group, or Rotenone + NDI1 group compared with Rotenone + vector group, or Rotenone + NDI1 group compared with DMSO + vector group, ns not significant. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658