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Fig. 1 | Molecular Medicine

Fig. 1

From: Antibody-drug conjugates targeting CD248 inhibits liver fibrosis through specific killing on myofibroblasts

Fig. 1

CD248 was mainly expressed on myofibroblasts in liver fibrosis. A Sirius red staining and IHC staining of CD248 in the liver tissue of 9 heathy controls and 40 patients with liver cirrhosis. B Quantitative analysis of the data in A. C Sirius red staining and IHC staining of CD248 in the liver tissue of CCl4-induced mice. D Quantitative analysis of the data in C. E, F qRT-PCR and western blotting analysis to show the increased expression of α-SMA, Collagen I, and CD248 in the liver tissues of CCl4-induced mice (n = 3 in BF). G IF staining images showing the colocalization of CD248 and α-SMA in the liver tissue of CCl4-induced mice. Representative images are shown. Scale bar, 100 μm; **p < 0.01, ***p < 0.001. IHC immunohistochemistry, qRT-PCR quantitative real-time reverse transcription polymerase chain reaction, α-SMA alpha smooth muscle actin, IF immunofluorescence

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