Fig. 2

Influence of resveratrol on gut microbiota in the progression of liver fibrosis in mice. Balb/c male mice (6–7 weeks old) were intraperitoneally injected with olive oil or CCl₄ (0.5 µL/g) to induce liver fibrosis for 4 weeks twice a week, and the mice were treated with 30 mg/kg resveratrol daily by gavage. Feces were collected for 16S rRNA sequencing in the fourth week. A, B The diversity and composition of microbial communities were evaluated using alpha-diversity and beta-diversity analysis, one-way ANOVA with Tukey’s post-hoc. C Genus analysis. D, E The dominant bacterial communities were assessed using Ternaryplot analysis and Top Ten abundance on species. F Analysis of the relative abundance of species, Z-score. *P < 0.05, **P < 0.01 vs. Control or CCl₄. Data are presented of three independent assays