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Fig. 6 | Molecular Medicine

Fig. 6

From: Resveratrol ameliorates liver fibrosis induced by nonpathogenic Staphylococcus in BALB/c mice through inhibiting its growth

Fig. 6

Influence of Staphylococcus_xylosus and Staphylococcus_lentus on the improvement of resveratrol on liver fibrosis. The pure cultures of the Staphylococcus_lentus and Staphylococcus_xylosus (109 CFU) were given to mice by gavage, and then the liver fibrosis model of mice was induced by the intraperitoneal injection of CCl4 (0.5 µL/g), and the mice were treated with resveratrol (30 mg/kg) daily by gavage. A The protocol for in vivo assays, and representative images of Sirius red staining (scale bar = 50 µm) and Immunohistochemical staining (scale bar = 50 µm) of α-SMA on mouse liver tissues. N = 6. B Quantitative results for the Sirius red staining. Brown-Forsythe and Welch ANOVA with Games-Howell’s post-hoc, Mean ± SD, N = 6. C Quantitative results for the Immunohistochemical staining of α-SMA. Brown-Forsythe and Welch ANOVA with Games-Howell’s post-hoc, Mean ± SD, N = 6. D The concentrations of ALT, AST and ALP in the mouse blood samples were measured using different detection kits, ALT, AST: Brown-Forsythe and Welch ANOVA with Games-Howell’s post-hoc; ALP: one-way ANOVA with Tukey's post-hoc, Mean ± SD, N = 10. E Comparison of the Hyp level by a commercial kit, one-way ANOVA with Tukey’s post-hoc, Mean ± SD, N = 10. F Analysis of the concentration of LBP in the mouse blood samples using a commercial kit, Brown-Forsythe and Welch ANOVA with Games-Howell’s post-hoc, Mean ± SD, N = 10. G The mRNA levels of ZO-1 and occludin were assessed by qRT-PCR. N = 10. H The relative ZO-1 positive areas were measured using immunofluorescence (scale bar = 50 µm). N = 6. **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. Control. #P < 0.05, ##P < 0.01, ###P < 0.001 vs. CCl4. aP < 0.05, aaP < 0.01, aaaP < 0.001, aaaaP < 0.0001 vs. CCl4 + resveratrol. Data are presented of three independent assays

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