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Fig. 4 | Molecular Medicine

Fig. 4

From: Involvement of the TNF-α/SATB2 axis in the induced apoptosis and inhibited autophagy of osteoblasts by the antipsychotic Risperidone

Fig. 4

Risperidone induces an increase of TNF-α expression and a decrease of SATB2 expression. A relative mRNA expression of TNF-α and SATB2 determined by RT-qPCR in control and Risperidone-treated MC3T3-E1 cells. B–C Western blot analysis of TNF-α and SATB2 protein expression in control and Risperidone-treated MC3T3-E1 cells. The band intensity was assessed. D relative mRNA expression of TNF-α and SATB2 was detected by RT-qPCR in MC3T3-E1 cells. E Western blot analysis of TNF-α and SATB2 protein expression in MC3T3-E1 cells. *p < 0.05, compared with control cells or MC3T3-E1 cells treated with si-NC. #p < 0.05, compared with MC3T3-E1 cells treated with Risperidone + si-NC. &p < 0.05, compared with MC3T3-E1 cells treated with Risperidone + si-TNF-α. The experiments are repeated 3 times

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Molecular Medicine

ISSN: 1528-3658