Fig. 6

A LASSO coefficients profiles of LAMB3, FN1, KRT19, and ANXA1 are shown by lambda parameter in relation to DFS. B LASSO Cox regression with ten-fold cross-validation obtained using minimum lambda value related to DFS. C Prognostic analysis of LAMB3, FN1, KRT19, and ANXA1 signatures in the TCGA set related to DFS. Top: The dotted line represents the median risk score and divides the patients into low-risk and high-risk groups. Middle: Survival status of the patients are shown in red (alive) and blue (dead) dots. Down: Heatmap of the expression profiles of the four prognostic genes (LAMB3, FN1, KRT19, and ANXA1) in the low- and high-risk groups relating to DFS. D The Kaplan–Meier DFS curves for PC patients assigned to low-risk and high-risk groups. The blue line represents the low-risk group and the red line the high-risk group. E ROC curves showing the predictive efficiency of the LAMB3, FN1, KRT19, and ANXA1 signatures relating to DFS on the 1-year, 3-year, and 4-year survival rate. (F) LASSO coefficients profiles of LAMB3, FN1, KRT19, and ANXA1 are shown by lambda parameter relating to OS. G LASSO Cox regression with ten-fold cross-validation obtained using minimum lambda value related to OS. H Prognostic analysis of LAMB3, FN1, KRT19, and ANXA1 signatures in the TCGA set relating to OS. The dotted line represents the median risk score and divides the patients into a low-risk and a high-risk group. Survival status of the patients are shown in red (alive) and blue (dead) dots. Heatmap of the expression profiles of the prognostic genes (LAMB3, FN1, KRT19, and ANXA1) showing in the low- and high-risk groups related to OS. (I) The Kaplan–Meier OS curves for PC patients assigned to the low-risk and high-risk groups. The blue line represents the low-risk group and the red line the high-risk group. J ROC curves showing the predictive efficiency of the LAMB3, FN1, KRT19, and ANXA1 signatures relating to OS on the 1-year, 3-year, and 4-year survival rate