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Fig. 6 | Molecular Medicine

Fig. 6

From: Hypermethylation of TMEM240 predicts poor hormone therapy response and disease progression in breast cancer

Fig. 6

Network analysis of TMEM240 involved in estrone and estradiol metabolism. MetaCore Metabolic Networks (Endogenous) analysis found that TMEM240 was involved in the metabolic networks of steroid, estrone, and estradiol metabolism (A). TMEM240, which is involved in estradiol metabolism, was identified with MetaCore Pathway Maps (B). RNA-seq indicated decreases in CYP2B6, CYP11B1, CYP2C8, CYP2C9, CYP3A4, CYP2E1, HSD17B3, SULT2A1, SULT1B1, and UGT2A1 mRNA expression and increases in CYP2C19, CYP3A5, CYP3A7, SULT1E1, UGT1A4, and UGT2B7 mRNA expression under TMEM240 overexpression compared to the vector control. The enzymes are responsible for Androstenedione, Estrone, Estradiol, and Estriol metabolism processes

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Molecular Medicine

ISSN: 1528-3658