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Fig. 6 | Molecular Medicine

Fig. 6

From: Protective role of trametenolic acid B against sevoflurane-induced cognitive impairments by its different regulatory modalities of mir-329-3p in neurons and microglia

Fig. 6

miR-329-3p directly targeted E2F1 and inhibited the E2F1/CCNA2 pathway in PC12 cells. A The complementary sequence of miR-329-3p at the 3'-UTR of E2F1. B miR-329-3p significantly inhibited the relative luciferase activity in PC12 cells with WT-E2F1 (*P < 0.05). C E2F1 mRNA expression was enhanced by TAB in PC12 cells exposed to sevoflurane, and this effect was further enhanced by miR-329-3p inhibition, but was weakened by miR-329-3p overexpression (***P < 0.05 compared to SEV; #P <0.05, ###P < 0.001 compared to SEV+TAB). D miR-329-3p overexpression significantly inhibited the protein expression of E2F1 and CCNA2, while miR-329-3p reduction led to the opposite effects on E2F1 and CCNA2 protein expression (*P < 0.05 compared to SEV; #P <0.05 compared to SEV+TAB)

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Molecular Medicine

ISSN: 1528-3658