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Fig. 5 | Molecular Medicine

Fig. 5

From: EGF signaling promotes the lineage conversion of astrocytes into oligodendrocytes

Fig. 5

EGF infusion promotes the transdifferentiation of astrocytes to oligodendrocytes in vivo. A Experimental design for analyzing the effect of EGF signaling during Sox10 virus-induced reprogramming in vivo. B Representative pictures of hGFAPCre-ER:Rosa26-tdTomato transgenic mice infused with PBS, Gefitinib, EGF or EGF + Gefitinib during Sox10-based reprogramming and immunostained for CC1. Scale bars, 50 μm. C Quantification of the percentage of CC1+ oligodendrocytes. Statistical analyses are presented as Mean ± SD, n = 3. *P < 0.05, **P < 0.01

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