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Fig. 5 | Molecular Medicine

Fig. 5

From: Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways

Fig. 5

- Effects of Glab on the level of oxidative stress associated parameters, AGEs, and ferroptosis markers in the kidneys of the DM rats. The levels of (A) advanced glycation end products (AGEs), (B) reactive oxygen species (ROS), (C) malondialdehyde (MDA), (D) catalase (CAT), (E) glutathione (GSH), (F) superoxide dismutase (SOD), and (G) iron concentration determined by commercial kits. The expression of ferroptosis markers (GPX4, SLC7A11, SLC3A2, and TFR1) at (H) mRNA and (I) protein levels were detected by RT-qPCR and western blot, respectively (***P < 0.005, vs. the control group; ##P < 0.01 and ###P < 0.005, vs. the DM group)

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Molecular Medicine

ISSN: 1528-3658