Fig. 1

MAIT cells are positively associated with adaptive immune responses to BNT162b2 mRNA vaccination. A Schematic description of the vaccine study. Representative flow cytometry plots (B) and combined data of MAIT cell percentage (C) in the healthy donor (HD) group at consecutive time points (n = 36–42). D CD40L+CD69+CD4 T cells in the HD group after SARS-CoV-2 spike peptide pool stimulation (n = 42). Correlation between the percentage of CD40L+CD69+CD4 T cells at day 35 (n = 42) and the MAIT cell percentage at day 0 (n = 42) (E) and day 35 (n = 42) (F). G Spike antibody titer at different time points in the HD group (n = 40–42). H Correlation between the MAIT cell percentage at day 35 (n = 42) and the spike antibody titer at day 35 (n = 42). Box plot indicates the median and interquartile range and whisker bars the 10th and 90th percentile. Mann–Whitney test was performed in D. Kruskal–Wallis test followed by Dunn’s multiple comparison test was performed in G. Correlation was assessed using the Spearman rank correlation test in E, F, and H. ***p < 0.005, ****p < 0.0001. A Was created using Biorender