Fig. 1

α7nAChR agonist GTS-21 treatment attenuates dextran sodium sulphate (DSS)-induced colitis. A Disease activity index (DAI) scores on day 8 was evaluated. *p < 0.05; **p < 0.01. B Colon length on day 8. *p < 0.05; **p < 0.01. C Weight change (%) from day 0 to day 8. *p < 0.05; **p < 0.01(GTS-21+DSS vs. DSS alone). D Gross macroscopic inflammation and length of the large bowel in each group. E Hematoxylin and eosin (H&E) was performed on paraffin-embedded distal colon tissue. Magnification: upper panels, ×100; lower panels, ×400. F Histopathological Index. **p < 0.01. All data represent as mean ± SEM of 8 mice per group. Scale bar, 500 nm