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Fig. 5 | Molecular Medicine

Fig. 5

From: α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates DSS-induced intestinal colitis by improving intestinal mucosal barrier function

Fig. 5

GTS-21 attenuates NF-қB activation in the intestinal tissues both in DSS-induced colitis and Caco2 monolayers. A Western blot analysis of NF-κB associated proteins (phosphorylated and non-phosphorylated IκBα, NF-қB p65) expressions level in colonic tissues, *p < 0.05, **p < 0.01. B Western blot analysis of NF-κB associated proteins (phosphorylated and non-phosphorylated IκBα, NF-қB p65) expressions level in Caco2 cells incubated with TNF-α for 30 min, *p < 0.05, **P < 0.01, ***p < 0.001. C The activation of NF-κB was detected by NF-κB nuclear translocation assays. Representative immunofluorescence of p65 (red) in Caco2 monolayers. (DAPI nuclear staining). Magnification, ×400. Scale bar, 100 nm

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