Fig. 2
From: Antidotal treatment of botulism in rats by continuous infusion with 3,4-diaminopyridine
Correlation of infusion dose and 3,4-DAP CSS after 24 h. Catheterized rats (n = 7) were subcutaneously infused for 24 h with 3,4-DAP at 0 (saline vehicle), 0.36, 0.72 and 1.44 mg/kg h, with a 5-day washout between doses. Serum was collected after 24 h and analyzed for 3,4-DAP. A Summary of experimental strategy. B Mean ± SD values for serum 3,4-DAP concentrations after 24 h infusion at each infusion dose rate. Linear regression demonstrated a strong fit between serum 3,4-DAP levels and infusion dose rate (R2 = 0.94)