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Fig. 3 | Molecular Medicine

Fig. 3

From: UBE2S promotes the development of ovarian cancer by promoting PI3K/AKT/mTOR signaling pathway to regulate cell cycle and apoptosis

Fig. 3

The expression of UBE2S in OV according to high-throughput database and low-throughput in vitro experiments. A The mRNA expression level of UBE2S in ovarian cancer tissues and corresponding control tissues based on six GEO database (GSE14407, GSE18520, GSE40595, GSE26712, GSE38666 and GSE54388). B Scatter plot of UBE2S expression levels in ovarian cancer tissues and corresponding control according to TCGA data (tumor = 427, normal = 88). C Survival curve of UBE2S high/low expression group in ovarian cancer GEO dataset GSE18520 (HR 4.02, P = 0.000082). D Survival curve of UBE2S high/low expression group in ovarian cancer GEO dataset GSE63885 (HR 2.04, P = 0.0071). E The mRNA expression levels of UBE2S in OV cell lines (SKOV3, A2780, OVCAR4) and normal cell lines (IOSE80) based on RT-qPCR. F The protein expression levels of UBE2S in ovarian cancer cell lines (A2780, SKOV3, OVCAR4) and a normal ovarian cell line (IOSE80) based on western blotting in this study

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Molecular Medicine

ISSN: 1528-3658