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Fig. 7 | Molecular Medicine

Fig. 7

From: BNIP3 mediates the different adaptive responses of fibroblast-like synovial cells to hypoxia in patients with osteoarthritis and rheumatoid arthritis

Fig. 7

Under hypoxic conditions, the occurrence of mitophagy and the regulation of BNIP3. Under hypoxia, RA-FLSs mediated mitophagy through high expression of BNIP3 to eliminate excess ROS in cells, maintain redox balance, reduce the occurrence of apoptosis, and promote cell survival. The expression of BNIP3 in OA-FLSs was relatively small, and the mitophagy mediated by it was not enough to eliminate excess ROS in cells, resulting in increased apoptosis and decreased cell survival

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Molecular Medicine

ISSN: 1528-3658