Fig. 2
From: RCAN1-mediated calcineurin inhibition as a target for cancer therapy
The signaling pathway of RCAN1 in tumor progression. A RCAN1 inhibits CN activity by blocking the CN-essential substrate recruitment site, LxVP and PxIxIT interaction grooves, by using its LxVP and PxIxIT motif. The inhibition of CN by RCAN1 can be weakened by phosphorylation of RCAN1. B RCAN1-regulated CN. RCAN1 inhibits CN-NFAT pathway and NFAT-regulated gene transcription, including IGF-1, VEGFA, ANG-2, IFI27, CXCL8, IL-8, and IL-11. C CN-independent RCAN1 regulation. GC binds to GREs in the RCAN1.1 transcription start site, inducing apoptosis cells. RCAN1 inhibits NFE2L3 and the NF-κB signaling pathway