From: RCAN1-mediated calcineurin inhibition as a target for cancer therapy
The effects on RCAN1 activity | Molecules of phosphorylate RCAN1 | Phosphorylation site | References |
---|---|---|---|
Accelerate dissociation of the RCAN1-CN complex and increases CN activity | MEK5-BMK1-MEKK3 complex | Serine-108 and serine-112 | |
TAK1–TAB1–TAB2 complex | Serine-94 or serine-136 sites | Liu et al. (2009) | |
MAPK | Serine-112 | Vega et al. (2002) | |
GSK-3β | Serine-108 | Jung et al. (2011) | |
ERK2 | Serine-112 | Vega et al. (2002) | |
P38MAPK | Serine-93, -108, -112; threonine-124, -153 | Ma et al. (2012) | |
Enhance RCAN1’s ability to inhibit the CN-NFAT pathway | NIK | – | Lee et al. (2008) |
DYRK1A | Serine-112 and threonine-192 | Smith (1998) | |
PKA | – | Kim et al. (2012) |