Skip to main content

Table 1 The molecules of phosphorylated RCAN1

From: RCAN1-mediated calcineurin inhibition as a target for cancer therapy

The effects on RCAN1 activity

Molecules of phosphorylate RCAN1

Phosphorylation site

References

Accelerate dissociation of the RCAN1-CN complex and increases CN activity

MEK5-BMK1-MEKK3 complex

Serine-108 and serine-112

Abbasi et al. (2006); Abbasi et al. (2005)

TAK1–TAB1–TAB2 complex

Serine-94 or serine-136 sites

Liu et al. (2009)

MAPK

Serine-112

Vega et al. (2002)

GSK-3β

Serine-108

Jung et al. (2011)

ERK2

Serine-112

Vega et al. (2002)

P38MAPK

Serine-93, -108, -112; threonine-124, -153

Ma et al. (2012)

Enhance RCAN1’s ability to inhibit the CN-NFAT pathway

NIK

–

Lee et al. (2008)

DYRK1A

Serine-112 and threonine-192

Smith (1998)

PKA

–

Kim et al. (2012)