Skip to main content
Fig. 1 | Molecular Medicine

Fig. 1

From: Hydroxychloroquine induces apoptosis of myeloid-derived suppressor cells via up-regulation of CD81 contributing to alleviate lupus symptoms

Fig. 1

Amelioration of HCQ on IMQ-induced lupus inhibits MDSCs expansion. A Kidney histopathological evaluation by H&E and PAS staining in the control groups, IMQ groups, HCQ groups and IMQ + HCQ groups (n = 4 mice/group). Bar = 50 μm. B The frequency of MDSCs in blood and spleen and the statistical results of the frequency of MDSCs from control groups, IMQ groups, HCQ groups and IMQ + HCQ groups (n = 6 mice/group). C The purity of MDSCs isolated from spleen was assessed by a MDSC Isolation Kit. D Cells from spleen of normal C57BL/6J female mice were co‑cultured with or without MDSCs from mice of different groups in different ratios (MDSCs: Splenocytes) at 1:2 and 1:4, respectively for 3 days. CFSE was distributed equally in proliferative CD4+ T cells. E The mRNA expression levels of MDSCs function-related genes in MDSCs isolated from spleen was measured by qRT-PCR (n = 4 mice/group). Data represent the mean scores ± SEM. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001

Back to article page