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Fig. 2 | Molecular Medicine

Fig. 2

From: Hydroxychloroquine induces apoptosis of myeloid-derived suppressor cells via up-regulation of CD81 contributing to alleviate lupus symptoms

Fig. 2

HCQ induces apoptosis of MDSCs and increases the level of CD81 in MDSCs. A Immunofluorescence detection of the apoptotic effects of HCQ on Gr-1+ cells in spleen. Scale bar = 50 μm (n = 3 mice/group). B The percentage of Annexin V+ in MDSCs in blood and spleen was determined by FACS (n = 6 mice/group). C The percentages of CD81+ in MDSCs were determined by FACS in blood and spleen (n = 6 mice/group). D Western blot was used to detect the protein expression of CD81 in purified MDSCs isolated from spleen (n = 4 mice/group). Data are presented as the mean ± standard error of the mean (SEM). *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001

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