Fig. 7

A Relationships between the numbers of miR-155 target genes predicted by the four tools used in this study. B Prediction of the transcription start site in the 5000 bases upstream of the 5' end of the first exon of INPP5D. C Cell survival rates of HUVECs treated with nucleic acid NFs S1–S8 activating SHIP1 at 12 h, 24 h, 48 h, and 72 h (*P < 0.05 vs. control). D SHIP1 expression in cells treated with nucleic acid NFs S1–S8 for 72 h (*P < 0.05 vs. control; **P < 0.01 vs. control). E Control cells cultured in the absence of NFs (magnification,4 ×). F Cell state at 72 h after miR-155 expression activation (magnification, 4 ×). G Cell state at 72 h after SHIP1 expression activation (magnification,10 ×). H Simultaneous activation of miR-155 and SHIP1 expression (magnification,10 ×). I Relative expression levels of SHIP1 and miR-155 in HUVECs treated with NF-M5, NF-S4, NF-M5, and NFs-S4 for 72 h (**P < 0.01 vs. control; ***P < 0.001 vs. control).