Fig. 2From: Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytesTHRSP silencing alters adipocyte metabolism pathways in adipocytes. a, b To study the impact of low THRSP levels on adipocyte function and gene expression, adipocytes were transfected with non-targeting control siRNA (SS2) or THRSP siRNA (siRTHRSP; n = 5, two independent experiments). c RNA sequencing of the transfected cells revealed significant down regulation of 2124 genes and an increase of 2049 genes’ expression upon THRSP silencing (n = 4). d GSEA pathway analysis showed 38 significantly altered pathways with negative and 32 with positive NES score. The data is represented as mean with SD. Statistical significance is designated as *P ≤ 0.05 (a, b). The transcriptomic data with adjusted P value (Padj) ≤ 0.05 was considered as statistically significantBack to article page