Fig. 3
THRSP silencing and insulin targeted common pathways. a Venn diagram indicates the number of significantly altered genes in THRSP silencing in blue, hyperinsulinemia in red and overlapping significantly altered genes in the middle. b GSEA Reactome analysis was conducted from the transcriptome of human AT obtained during hyperinsulinemic clamp. Pathways affected by insulin infusion were compared to the pathways altered by THRSP silencing. There was 10 common pathways inversely altered. NES score is indicated by color and the set size by symbol size. c Significantly altered common metabolic pathways’ gene expression. Statistical significance is denoted as *Padj ≤ 0.05, **Padj < 0.01, ***Padj < 0.001, ****Padj < 0.0001