Fig. 4
Mitochondrial function is dampened by THRSP silencing in adipocytes. a Oxidation, citric acid cycle and respiratory electron transport associated genes were affected by THRSP silencing. The heatmap represents log2 fold-change (log2 FC) of significantly altered genes (Padj ≤ 0.05). b Oxidation of [3H] oleate (n = 9, two independent experiments). c Oxygen consumption rate (OCR) measured in control (ss2), THRSP silencing (siR), overexpression control (oex ctrl) and overexpression (oex) (Two independent experiments with multiple replicates). d) Uptake of [3H] glucose in THRSP silenced adipocytes with or without insulin (n = 12, two independent experiments). Statistical significance is designated as *P ≤ 0.05 **P < 0.01, ****P < 0.0001