Fig. 6

Schematic representation indicating sphingolipid metabolism genes downregulated in THRSP-silenced adipocytes. The figure represents sphingolipid metabolism, where the altered genes are designated by blue color. Saposin (SAP) below the gene name indicates activation by SAPs. GalCeramide, galactosylceramide; GlcCeramide, galactorylceramide; LacCeramide, lactosylceramide, CST, cystatin; ARSA, arylsulfatase A; SAP, saposin; UGT8, UDP glycosyltransferase 8; GALC, galactosylceramidase; SGMS, sphingomyelin synthase; SMDP, Sphingomyelin phosphodiesterase; UGCG, UDP-glucose ceramide glucosyltransferase; GBA, glucosylceramidase beta; B4GALT5/6, beta-1,4-galactosyltransferase 5/6; GLB1, galactosidase beta 1; B3GNT5, beta-1,3-N-acetylglucosaminyltransferase 5; B3GALT5, beta-1,3-galactosyltransferase 5; ST3GAL3, ST3 beta-galactoside alpha-2,3-sialyltransferase 3; NEU, neuraminidase; HEXB, hexosaminidase subunit beta; HEXA, hexosaminidase subunit alpha; GM2A, GM2 ganglioside activator; ST3GAL2/3, ST3 beta-galactoside alpha-2,3-sialyltransferase 2/3; B3GALT4, beta-1,3-galactosyltransferase 4; B4GALNT1, beta-1,4-N-acetyl-galactosaminyltransferase 1; ST3GALT5, ST3 beta-galactoside alpha-2,3-sialyltransferase 5; GLA, galactosidase alpha; B3GALNT1, beta-1,3-N-acetylgalactosaminyltransferase 1; A4GALT, alpha 1,4-galactosyltransferase