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Fig. 1 | Molecular Medicine

Fig. 1

From: Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases

Fig. 1

5-HT7 and 5-HT1A receptor signaling pathways and oligo/heterodimer formation. 5-HT7 receptor monomers (in yellow) can form homodimers or homoligomers, with the same signaling pathways and cellular effects. 5-HT7 can also form heterodimers or heteroligomers with 5-HT1A (in teal), resulting in the inhibition of the 5-HT1A signaling pathway, with no net effect downstream of 5-HT7. When activated, 5-HT7 activates Gas (canonical pathway) with a subsequent signaling cascade that results in the activation of ERK (also known as MAPK) and Akt; in contrast, the activation of Ga12 activates mTOR and different Rho family small GTPases. As illustrated, the phosphorylation of Trkb is mediated by both G proteins. AC adenylate cyclase, cAMP cyclic adenosine monophosphate, Cdc42 cell division control protein 42 homolog, ERK extracellular signal-regulated kinases, MAPK mitogen-activated protein kinases, mTOR mammalian target of rapamycin, Trkb Tropomyosin receptor kinase B

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