Fig. 2
From: Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases
Cellular and molecular effects of 5-HT7 receptors. Molecular effects of 5-HT7 activation. A When activated, 5-HT7 receptors modulate ion transmission through enhancing LTP and LTD (1); these receptors also increase the number of neurotrophins (especially BDNF) and the affinity of its receptor Trkb (2); through ERK and Akt, 5-HT7 decreases neuronal damage mediated by ROS (3); and reduces the excitotoxicity burden mediated by glutamate-NMDA-calcium. Cellular effects of 5-HT7 activation. B When stimulated by serotonin, 5-HT7 enhances dendritic sprouting and synaptogenesis, while regulating (often towards suppression) immune cells. LTD long-term depression, LTP long-term potentiation, NMDA (N-methyl-d-aspartate receptor, ROS reactive oxygen species, Trkb tropomyosin receptor kinase B