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Fig. 3 | Molecular Medicine

Fig. 3

From: m6A-modified circRNAs: detections, mechanisms, and prospects in cancers

Fig. 3

Role of M6A modifications on circRNAs. A M6A modification mediates circRNAs translation. M6A-driven translation of circRNAs relies on YTHDF3, eIF4G2 and eIF3A. Meanwhile, the process can be enhanced by METTL3/14 and inhibited by FTO. Besides, it is suggested that an interaction may exist between the IRES-driven translation and m6A-driven translation. B M6A modification mediates circRNAs nucleoplasmic transport. The m6A readers, such as YTHDC1 and FMRP, could induce the nuclear and cytoplasmic transport of circRNAs. C M6A modification regulates the stability of circRNAs. M6A-modified circRNAs can be endoribonuclease-cleaved via YTHDF2-HRSP12-RNase P/MRP axis

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