From: m6A-modified circRNAs: detections, mechanisms, and prospects in cancers
Cancer | CircRNA name | Regulation | M6A component | Fuction | Role in cancer | M6A identification methods and databases | Main mechanisms | References |
---|---|---|---|---|---|---|---|---|
CRC | circ3823 | Up | ALKBH5/YTHDF2/YTHDF3 | Eraser/reader/reader | Anti-oncogene | MeRIP assay, GEO and TCGA databases | Sponge miR-30c-5p to upregulate TCF7 expression | Guo et al. (2021) |
CRC | circ1662 | Up | METTL3 | Writer | Oncogene | MeRIP assay | Bind to YAP1 protein and promote its nuclear transport to regulate SMAD3 | Chen et al. (2021) |
CRC | circNSUN2 | Up | YTHDC1/IGF2BP2 | Reader/reader | Oncogene | MeRIP assay | Bind to YTHDC1 and promote its export to the cytoplasm, as well as stabilize HMGA2 mRNA via circNSUN2-IGF2BP2-HMGA2 axis | Chen et al. (2019b) |
PDGA | A series of circRNAs (circ0077837) | Up/down (down) | – | – | – | SRAMP, m6A RIP | - | Zhang et al. (2020) |
GC | circORC5 | Up | METTL14 | Writer | Anti-oncogene | m6A-circRNA epitranscriptomic microarray, MeRIP assay | Sponge miR-30c-2-3p to regulate AKT1S1 and EIF4B expression | Fan et al. (2022) |
HCC | circMAP2K4 | Up | YTHDF1 | Reader | Oncogene | TCGA and ICGC databases | Sponge hsa-miR-139-5p to regulate the expression of YTHDF1 | Chi et al. 2021) |
HCC | circDLC1 | Down | KIAA1429 | Writer | Oncogene | m6A-seq | Bind to HuR protein and block the interaction between HuR and MMP1 mRNAs | Liu et al. (2021) |
HCC | circHPS5 | Up | METTL3/YTHDC1 | Writer/reader | Oncogene | MeRIP-seq, SRAMP, m6A RIP | Sponge miR-370 to regulate HMGA2 expression and expedite its cytoplasmic output | Rong et al. (2021) |
BC | circMETTL3 | Up | METTL3/METTL14/FTO | Writer/writer/eraser | Oncogene | circBank, m6A RIP | Sponge miR-31-5p to upregulate CKD1 expression | Li et al. 2021a) |
CC | circE7 | Up | METTL3 | Writer | Oncogene | m6A RIP | Translate into E7 oncoprotein | Zhao et al. (2019) |
CC | circARHGAP12 | Up | IGF2BP2 | Reader | Oncogene | MeRIP assay | Bind to IGF2BP2 to enhance FOXM1 mRNA stability | Ji et al. (2021) |
NSCLC | circNDUFB2 | Down | METTL3/METTL14/IGF2BPs | Writer/writer/reader | Oncogene | MeRIP assay | Act as a scaffold by forming a TRIM25/circNDUFB2/IGF2BPs ternary complex to facilitate the degradation of IGF2BPs and trigger cellular immune responses by activating RIG-I | Li et al. (2021b) |
Glioma | circDLC1 | Down | METTL3 | Writer | Anti-oncogene | m6A level detection, MeRIP assay | Sponge miR-671-5p to facilitate the transcription of CTNNBIP1 | Wu et al. (2022) |
Sorafenib-resistant hepatocellular carcinoma | circRNA-SORE | Up | METTL3/METTL14/FTO | Writer/writer/eraser | Oncogene | SRAMP, RMBase v2.0, MeRIP assay | Sponge miR-103a-2-5p and miR-660-3p to activate Wnt/β-catenin pathway | Xu et al. (2020) |
HCC | circMAP3K4 | Up | IGF2BP1 | Reader | Oncogene | SRAMP, MeRIP assay | Translate into circMAP3K4-455aa | Duan et al. (2022) |
Radiotherapy-resistant hypopharyngeal squamous cell carcinoma | circCUX1 | Up | METTL3 | Writer | Oncogene | MeRIP assay | Bind to caspase 1 mRNA and inhibit its expression | Wu et al. (2021) |