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Table 3 Roles of m6A-modified circRNAs in various cancers

From: m6A-modified circRNAs: detections, mechanisms, and prospects in cancers

Cancer

CircRNA name

Regulation

M6A component

Fuction

Role in cancer

M6A identification methods and databases

Main mechanisms

References

CRC

circ3823

Up

ALKBH5/YTHDF2/YTHDF3

Eraser/reader/reader

Anti-oncogene

MeRIP assay, GEO and TCGA databases

Sponge miR-30c-5p to upregulate TCF7 expression

Guo et al. (2021)

CRC

circ1662

Up

METTL3

Writer

Oncogene

MeRIP assay

Bind to YAP1 protein and promote its nuclear transport to regulate SMAD3

Chen et al. (2021)

CRC

circNSUN2

Up

YTHDC1/IGF2BP2

Reader/reader

Oncogene

MeRIP assay

Bind to YTHDC1 and promote its export to the cytoplasm, as well as stabilize HMGA2 mRNA via circNSUN2-IGF2BP2-HMGA2 axis

Chen et al. (2019b)

PDGA

A series of circRNAs (circ0077837)

Up/down (down)

–

–

–

SRAMP, m6A RIP

-

Zhang et al. (2020)

GC

circORC5

Up

METTL14

Writer

Anti-oncogene

m6A-circRNA epitranscriptomic microarray, MeRIP assay

Sponge miR-30c-2-3p to regulate AKT1S1 and EIF4B expression

Fan et al. (2022)

HCC

circMAP2K4

Up

YTHDF1

Reader

Oncogene

TCGA and ICGC databases

Sponge hsa-miR-139-5p to regulate the expression of YTHDF1

Chi et al. 2021)

HCC

circDLC1

Down

KIAA1429

Writer

Oncogene

m6A-seq

Bind to HuR protein and block the interaction between HuR and MMP1 mRNAs

Liu et al. (2021)

HCC

circHPS5

Up

METTL3/YTHDC1

Writer/reader

Oncogene

MeRIP-seq, SRAMP, m6A RIP

Sponge miR-370 to regulate HMGA2 expression and expedite its cytoplasmic output

Rong et al. (2021)

BC

circMETTL3

Up

METTL3/METTL14/FTO

Writer/writer/eraser

Oncogene

circBank, m6A RIP

Sponge miR-31-5p to upregulate CKD1 expression

Li et al. 2021a)

CC

circE7

Up

METTL3

Writer

Oncogene

m6A RIP

Translate into E7 oncoprotein

Zhao et al. (2019)

CC

circARHGAP12

Up

IGF2BP2

Reader

Oncogene

MeRIP assay

Bind to IGF2BP2 to enhance FOXM1 mRNA stability

Ji et al. (2021)

NSCLC

circNDUFB2

Down

METTL3/METTL14/IGF2BPs

Writer/writer/reader

Oncogene

MeRIP assay

Act as a scaffold by forming a TRIM25/circNDUFB2/IGF2BPs ternary complex to facilitate the degradation of IGF2BPs and trigger cellular immune responses by activating RIG-I

Li et al. (2021b)

Glioma

circDLC1

Down

METTL3

Writer

Anti-oncogene

m6A level detection, MeRIP assay

Sponge miR-671-5p to facilitate the transcription of CTNNBIP1

Wu et al. (2022)

Sorafenib-resistant hepatocellular carcinoma

circRNA-SORE

Up

METTL3/METTL14/FTO

Writer/writer/eraser

Oncogene

SRAMP, RMBase v2.0, MeRIP assay

Sponge miR-103a-2-5p and miR-660-3p to activate Wnt/β-catenin pathway

Xu et al. (2020)

HCC

circMAP3K4

Up

IGF2BP1

Reader

Oncogene

SRAMP, MeRIP assay

Translate into circMAP3K4-455aa

Duan et al. (2022)

Radiotherapy-resistant hypopharyngeal squamous cell carcinoma

circCUX1

Up

METTL3

Writer

Oncogene

MeRIP assay

Bind to caspase 1 mRNA and inhibit its expression

Wu et al. (2021)