Skip to main content

Table 1 Effect sizes of anesthesia-induced tau hyperphosphorylation immediately and 24 h after anesthesia

From: Anesthesia promotes acute expression of genes related to Alzheimer’s disease and latent tau aggregation in transgenic mouse models of tauopathy

 

Soluble cortex

Soluble hippocampus

 

RZ3

CP13

PHF1

RZ3

CP13

PHF1

 

Effect size (95% CI)

Effect size (95% CI)

Immediately after AN

      

COMTKO/P301L

(n per group = 8, 10)

0.060

(− 0.87,0.99)

3.57*

(2.08,5.07)

1.52*

(0.46,2.57)

0.48

(− 0.46,1.42)

1.65*

(0.57,2.72)

2.85*

(1.53,4.16)

P301L

(n per group = 8, 8/7)

1.12*

(0.06,2.17)

3.17*

(1.65,4.69)

1.01

(− 0.03,2.06)

0.98

(− 0.09,2.06)

1.38*

(0.25,2.51)

2.26*

(0.97,3.56)

24 h after AN

      

COMTKO/P301L

(n per group = 8, 8)

− 2.07*

(− 3.28,− 0.86)

− 0.38

(− 1.37,0.61)

− 1.20*

(− 2.27,− 0.14)

− 0.30

(− 1.28,0.69)

− 0.15

(− 1.13,0.83)

− 0.10

(− 1.08,0.89)

P301L

(n per group = 8, 8/7)

− 1.00

(− 2.04,0.04)

1.11*

(0.05,2.16)

− 0.07

(− 1.05,0.92)

− 0.08

(− 1.09,0.94)

− 0.15

(− 1.16,0.87)

0.52

(− 0.48,1.52)

  1. The level of hyperphosphorylation, as quantified by ELISA, in the mice either immediately or 24 h after anesthesia was compared to that of the control mice. Hedges’ g was calculated with 95% confidence intervals to estimate the effect size of the difference between two groups. Asterisk indicates that the 95% confidence interval does not include zero. Sample size for the control group is listed first in the first column. AN anesthesia, CI confidence interval
Back to article page

Molecular Medicine

ISSN: 1528-3658