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Table 1 Effect sizes of anesthesia-induced tau hyperphosphorylation immediately and 24 h after anesthesia

From: Anesthesia promotes acute expression of genes related to Alzheimer’s disease and latent tau aggregation in transgenic mouse models of tauopathy

  Soluble cortex Soluble hippocampus
  RZ3 CP13 PHF1 RZ3 CP13 PHF1
  Effect size (95% CI) Effect size (95% CI)
Immediately after AN       
COMTKO/P301L
(n per group = 8, 10)
0.060
(− 0.87,0.99)
3.57*
(2.08,5.07)
1.52*
(0.46,2.57)
0.48
(− 0.46,1.42)
1.65*
(0.57,2.72)
2.85*
(1.53,4.16)
P301L
(n per group = 8, 8/7)
1.12*
(0.06,2.17)
3.17*
(1.65,4.69)
1.01
(− 0.03,2.06)
0.98
(− 0.09,2.06)
1.38*
(0.25,2.51)
2.26*
(0.97,3.56)
24 h after AN       
COMTKO/P301L
(n per group = 8, 8)
− 2.07*
(− 3.28,− 0.86)
− 0.38
(− 1.37,0.61)
− 1.20*
(− 2.27,− 0.14)
− 0.30
(− 1.28,0.69)
− 0.15
(− 1.13,0.83)
− 0.10
(− 1.08,0.89)
P301L
(n per group = 8, 8/7)
− 1.00
(− 2.04,0.04)
1.11*
(0.05,2.16)
− 0.07
(− 1.05,0.92)
− 0.08
(− 1.09,0.94)
− 0.15
(− 1.16,0.87)
0.52
(− 0.48,1.52)
  1. The level of hyperphosphorylation, as quantified by ELISA, in the mice either immediately or 24 h after anesthesia was compared to that of the control mice. Hedges’ g was calculated with 95% confidence intervals to estimate the effect size of the difference between two groups. Asterisk indicates that the 95% confidence interval does not include zero. Sample size for the control group is listed first in the first column. AN anesthesia, CI confidence interval