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Table 2 Effect sizes of anesthesia-induced tau hyperphosphorylation one and three months after anesthesia

From: Anesthesia promotes acute expression of genes related to Alzheimer’s disease and latent tau aggregation in transgenic mouse models of tauopathy

 

Insoluble cortex

 

RZ3

CP13

PHF1

 

Effect size (95% CI)

One month after AN

   

COMTKO/P301L at 5 mo

(n per group = 12)

0.22

(− 0.58, 1.02)

0.09

(− 0.71, 0.89)

0.46

(− 0.35, 1.27)

Three months after AN

   

COMTKO/P301L at 7 mo

(n per group = 17, 13)

2.07*

(1.18, 2.96)

2.03*

(1.14, 2.91)

1.69*

(0.85, 2.53)

  1. The level of hyperphosphorylation, as quantified by ELISA, in the mice either one or three months after anesthesia was compared to that of the control mice. Hedges’ g was calculated with 95% confidence intervals to estimate the effect size of the difference between two groups. Asterisk indicates that the 95% confidence interval does not include zero. Sample size for the control group is listed first in the first column. AN anesthesia, CI confidence interval, mo months old
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