Fig. 8
Recombinant LAP and tLAP alleviate liver fibrosis through TGF-β/SMAD pathway. A Detection of the mRNA expression of αvβ6 in HSC-T6 cells. ***P < 0.001 vs control group; ##P < 0.01 vs TGF-β1 group. ###P < 0.001 vs TGF-β1 group; △△P < 0.01, TGF-β1 + tLAP group vs TGF-β1 + LAP group. B Detection of the mRNA expression of αvβ6 in C57BL/6 mice. **P < 0.01 vs control group; ***P < 0.001 vs control group; #P < 0.05 vs CCl4 group; ###P < 0.001 vs CCl4 group; △△P < 0.01, CCl4 + tLAP group vs CCl4 + LAP group. C Detection of the expression of αvβ6 in C57BL/6 mice. ***P < 0.001 vs control group; ##P < 0.01vs CCl4 group; ###P < 0.001 vs CCl4 group. D Detection of the expression of SMAD2 and p-SMAD2 in HSC-T6 cells. ***P < 0.001 vs control group; #P < 0.05 vs TGF-β1 group; ##P < 0.01 vs TGF-β1 group. E Detection of the expression of SMAD2 and p-SMAD2 C57BL/6 mice. ***P < 0.001 vs control group; ##P < 0.01 vs CCl4 group. ###P < 0.001 vs CCl4 group