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Fig. 4 | Molecular Medicine

Fig. 4

From: FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling

Fig. 4

After silencing FZD7 expression using lentiviral shRNAs, the counts and the diameters of cell spheres were significantly decreased during suspension culture (A), and the proportion of CD24+CD44+ cells in PANC-1 cell line was reduced from 23.6 to 9.8% (B). The spheroid-forming cell migration distance was larger than that in normal adherent culture cells (C), and the proportion of Transwell cells was higher than that of normal adherent culture cells (D). The spheroid-forming cell expressed higher levels of mesenchymal phenotype (E). Significant, *P < 0.05, **P < 0.01, ***P < 0.001, Student’s t-test

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