Table 3 The criteria obtained for WB and NP samples in the first and second phases by the RF classifier based on LASSOfeatures
Tissue | The first phase based on the k-fold CV on the train set | The second phase based on train and test sets | Number of features | Genes | ||||
|---|---|---|---|---|---|---|---|---|
Sensitivity_cv | Specificity_cv | Accuracy_cv | Sensitivity | Specificity | Accuracy | |||
WB | 0.895238095 | 0.855072464 | 0.879310345 | 0.90625 | 0.923076923 | 0.911111111 | 3 | CCDC27, CDCA5, EIF1AY |
0.971428571 | 0.898550725 | 0.942528736 | 0.90625 | 0.923076923 | 0.911111111 | 4 | CCDC27, HIST2H4A, NOS1AP, TRIP13 | |
0.971428571 | 0.927536232 | 0.954022989 | 0.90625 | 0.923076923 | 0.911111111 | 5 | CCDC27, HIST2H4A, LGSN, NOS1AP, TRIP13 | |
0.980952381 | 0.956521739 | 0.967816092 | 1 | 0.923076923 | 0.977777778 | 6* | C1QC, CCDC27, HIST2H4A, INSC, OTOF, SLC24A5 | |
0.980952381 | 0.956521739 | 0.967816092 | 1 | 0.923076923 | 0.977777778 | 6 | CCDC27, CDCA5, INSC, NMNAT2, OR2A42, SLC24A5 | |
0.980952381 | 0.913043478 | 0.948275862 | 1 | 0.923076923 | 0.977777778 | 7 | ABCC11, CCDC27, INSC, NMNAT2, OTOF, SLC24A5, TRIP13 | |
0.971428571 | 0.942028986 | 0.971264368 | 1 | 0.923076923 | 0.977777778 | 8 | ABCC11, CCDC27, CDCA5, GTF2H2C, INSC, OTOF, SLC24A5, SLC45A2 | |
0.971428571 | 0.971014493 | 0.977011494 | 1 | 0.923076923 | 0.977777778 | 9* | CCDC27, CDCA5, EIF1AY, GOLGA8M, GTF2H2C, INSC, NMNAT2, OTOF, SLC24A5 | |
0.971428571 | 0.971014493 | 0.977011494 | 1 | 0.923076923 | 0.977777778 | 9 | CCDC27, GSTM1, GTF2H2C, INSC, NMNAT2, NOS1AP, OTOF, SLC24A5, TRIP13 | |
NP | 0.861148198 | 0.777070064 | 0.822803195 | 0.815508021 | 0.785714286 | 0.808 | 3 | IFI6, MIF, NUCB1 |
0.891855808 | 0.805732484 | 0.852578068 | 0.855614973 | 0.825396825 | 0.848 | 4 | IFI6, LAMB3, MIF, NUCB1 | |
0.887850467 | 0.823248408 | 0.8583878 | 0.863636364 | 0.873015873 | 0.866 | 5 | IFI44L, IFI6, IL1R2, MIF, NUCB1 | |
0.903871829 | 0.824840764 | 0.867828613 | 0.852941176 | 0.857142857 | 0.854 | 6 | ADIRF, IFI6, IL1R2, MIF, NUCB1, TMA7 | |
0.910547397 | 0.837579618 | 0.877269426 | 0.868983957 | 0.873015873 | 0.87 | 7 | CXCL10, IFI6, MIF, NUCB1, SAMHD1, SIGLEC1, TMED9 | |
0.90787717 | 0.839171975 | 0.87654321 | 0.871657754 | 0.912698413 | 0.882 | 8 | COPA, CXCL11, IFI6, MIF, NUCB1, SAMHD1, SIGLEC1, TMED9 | |
0.90787717 | 0.855095541 | 0.883805374 | 0.871657754 | 0.904761905 | 0.88 | 9 | CXCL11, IFI6, IFIT2, LAMB3, MIF, NUCB1, SAMHD1, TMA7, XAF1 | |