Fig. 3Â
From: MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy
MALAT1-miRNAs network regulating the expression level of TYMS along with other cancer-related genes in various types of cancer. Cancer type designation: CRC, colorectal cancer; GC, gastric cancer; NSCLC, non-small cell lung cancer; BRCA, breast cancer; HCC, hepatocellular carcinoma. Red indicates oncogenic effects, green indicates tumor suppressor effects, blue indicates tumor suppressor or oncogenic effects depending on the type of cancer. YAP1 in complex with TCF4/β-catenin upregulates the expression of the MALAT1 gene in CRC and HCC (Sun et al. 2019b; Wang et al. 2014a)