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Table 11 Major genes targeted by miR-330-3p in various types of cancer

From: MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy

Cancers Targeted gene products References
Cancers with down-regulation of miR-330-3p
  Acting as oncogenes or tumor promoters
CRC TYMS, HK2 Xu et al. (2017); Gao et al. (2021a)
GC MSI1, PRRX1 Guan et al. (2016); Ma et al. (2020)
LSCC SLC7A11, TRA2B Fan and Zhu (2022); Cheng et al. (2020a)
OSCC GLS Qian et al. (2021)
BRCA MYC He et al. (2020)
PCa BMI1, E2F1 Li et al. (2020b); Lee et al. (2009)
  Acting both as oncogenes and tumor suppressors, or unclassified)
CRC MYO6, PFN1 Wang et al. (2022b); Huang et al. (2020b)
NSCLC GRIA3 Wei et al. (2019b)
OVCA RIPK4 Cai et al. (2021)
Cancers with up-regulation of miR-330-3p
  Acting as tumor suppressors  
ESCC PDCD4 Meng et al. (2015)
NSCLC EGR2, PTEN, RASSF1A Liu et al. (2015); Wang et al. (2021e); Chen et al. (2019b)
BRCA PDCD4 Ji et al. (2021)
HCC BTG1, ING4 Zhao et al. (2019b); Hu et al. (2017a)
  1. mRNAs encoding the following proteins: BMI1 encodes BMI1 Proto-Oncogene, Polycomb Ring Finger; BTG1 is a tumor suppressor gene that codes for BTG Anti-Proliferation Factor 1; EGR2 is a tumor suppressor gene that codes for transcription factor Early Growth Response 2; GLS encodes GLS1 (Glutaminase) which promotes proliferation as opposed to proliferation-inhibiting GLS2 (Kim and Kim 2013); GRIA3 encodes Glutamate Ionotropic Receptor AMPA Type Subunit 3; HK2 encodes Hexokinase 2 catalyzing the rate-limiting step of glucose metabolism and is highly expressed in rapidly growing cancer cells; ING4 encodes tumor suppressor protein that can bind p53; MSI1 encodes Musashi RNA-binding protein that is involved in tumorigenesis; MYC encodes transcription factor MYC Proto-Oncogene (c-Myc); MYO6 encodes motor protein Myosin VI; PFN1 encodes Profilin 1 that binds actin monomers and mediates actin polymerization but also inhibit formation of IP3 from PIP2; PDCD4 encodes programmed cell death protein 4 acting as a tumor suppressor; PRRX1 codes for Paired Related Homeobox 1 protein that can promote the EMT process in cancer cells (Du et al. 2021); RASSF1A is a tumor suppressor gene encoding Ras Association Domain Family Member 1; RIPK4 encodes Receptor Interacting Serine/Threonine Kinase 4 and acts as a tumor suppressor or promoter depending on the type of cancer (Xu et al. 2020c); SLC7A11 encodes Cystine/Glutamate Transporter (Koppula et al. 2021); TRA2B is an oncogene encoding Transformer 2 β Homolog