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Table 11 Major genes targeted by miR-330-3p in various types of cancer

From: MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy

Cancers

Targeted gene products†

References

Cancers with down-regulation of miR-330-3p

 

Acting as oncogenes or tumor promoters

CRC

TYMS, HK2

Xu et al. (2017); Gao et al. (2021a)

GC

MSI1, PRRX1

Guan et al. (2016); Ma et al. (2020)

LSCC

SLC7A11, TRA2B

Fan and Zhu (2022); Cheng et al. (2020a)

OSCC

GLS

Qian et al. (2021)

BRCA

MYC

He et al. (2020)

PCa

BMI1, E2F1

Li et al. (2020b); Lee et al. (2009)

 

Acting both as oncogenes and tumor suppressors, or unclassified)

CRC

MYO6, PFN1

Wang et al. (2022b); Huang et al. (2020b)

NSCLC

GRIA3

Wei et al. (2019b)

OVCA

RIPK4

Cai et al. (2021)

Cancers with up-regulation of miR-330-3p

 

Acting as tumor suppressors

 

ESCC

PDCD4

Meng et al. (2015)

NSCLC

EGR2, PTEN, RASSF1A

Liu et al. (2015); Wang et al. (2021e); Chen et al. (2019b)

BRCA

PDCD4

Ji et al. (2021)

HCC

BTG1, ING4

Zhao et al. (2019b); Hu et al. (2017a)

  1. †mRNAs encoding the following proteins: BMI1 encodes BMI1 Proto-Oncogene, Polycomb Ring Finger; BTG1 is a tumor suppressor gene that codes for BTG Anti-Proliferation Factor 1; EGR2 is a tumor suppressor gene that codes for transcription factor Early Growth Response 2; GLS encodes GLS1 (Glutaminase) which promotes proliferation as opposed to proliferation-inhibiting GLS2 (Kim and Kim 2013); GRIA3 encodes Glutamate Ionotropic Receptor AMPA Type Subunit 3; HK2 encodes Hexokinase 2 catalyzing the rate-limiting step of glucose metabolism and is highly expressed in rapidly growing cancer cells; ING4 encodes tumor suppressor protein that can bind p53; MSI1 encodes Musashi RNA-binding protein that is involved in tumorigenesis; MYC encodes transcription factor MYC Proto-Oncogene (c-Myc); MYO6 encodes motor protein Myosin VI; PFN1 encodes Profilin 1 that binds actin monomers and mediates actin polymerization but also inhibit formation of IP3 from PIP2; PDCD4 encodes programmed cell death protein 4 acting as a tumor suppressor; PRRX1 codes for Paired Related Homeobox 1 protein that can promote the EMT process in cancer cells (Du et al. 2021); RASSF1A is a tumor suppressor gene encoding Ras Association Domain Family Member 1; RIPK4 encodes Receptor Interacting Serine/Threonine Kinase 4 and acts as a tumor suppressor or promoter depending on the type of cancer (Xu et al. 2020c); SLC7A11 encodes Cystine/Glutamate Transporter (Koppula et al. 2021); TRA2B is an oncogene encoding Transformer 2 β Homolog
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Molecular Medicine

ISSN: 1528-3658