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Table 15 Major genes targeted by miR-433-3p in various types of cancer

From: MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy

Cancers Targeted gene products References
Cancers with down-regulation of miR-433-3p
  Acting as oncogenes or tumor promoters
CRC CREB1, HOXA1, MACC1, MAPK8 Yan et al. (2018); Li et al. (2018c); Li et al. (2017c)
GC KRAS Guo et al. (2013)
ESCC REV3L Li and Li (2021)
OSCC HDAC6, PAK4, PTK2 Wang et al. (2015); Liu et al. (2020b); Wang et al. (2017)
NSCLC E2F3, LPCAT1, SMAD2, NUCKS1 Liu et al. (2018); Guo et al. (2022); Li et al. (2019a); Yu et al. (2022)
BLCA CREB1 Xu et al. (2016b)
HCC CREB1 Yang et al. (2013)
PDAC GOT1 Zhou et al. (2021b)
CeCa TYMS, MTDH Gotanda et al. (2013); Liang et al. (2017)
  Acting both as oncogenes and tumor suppressors, or unclassified
CRC CCAR1 Yan et al. (2018)
GC ATG5, ATG12 Wang et al. (2021c)
ESCC HMGB1 Cheng et al. (2020b)
NSCLC TIPRL Zhang et al. (2021)
BLCA CCAR1 Wang et al. (2020b)
HCC CBX3, FXYD3 Song et al. (2021); Ma et al. (2021a)
OVCA NOTCH1 Liang et al. (2016)
  1. mRNAs encoding the following proteins: ATG5 and ATG12 code for Autophagy-Related Proteins 5 and 12, respectively; CBX3 encodes Chromobox Protein Homolog 3 and functions as both an oncogene and a tumor suppressor; CCAR1 codes for Cell Division Cycle And Apoptosis Regulator 1 that functions as a transcriptional coactivator; CREB1 codes for transcription factor cAMP Response Element Binding Protein 1; E2F3 is an oncogene coding for E2F Transcription Factor 3; FXYD3 codes for Sodium/Potassium-Transporting ATPase Subunit FXYD3; GOT1 codes for Glutamic-Oxaloacetic Transaminase 1 that functions as a tumor promoter in pancreatic cancer growth; HDAC6 encodes Histone Deacetylase 6; HOXA1 is an oncogene coding for transcription factor Homeobox A1 (Li et al. 2019b); KRAS encodes KRAS Proto-Oncogene (GTPase K-Ras); LPCAT1 is an oncogene encoding Lysophosphatidylcholine Acetyltransferase 1 (Wei et al. 2019c); MACC1 codes for Metastasis-Associated in Colon Cancer protein 1; MAPK8 codes for Mitogen-Activated Protein Kinase 8 and is involved in colon cancer chemoresistance (Wu et al. 2019); NOTCH1 encoding Notch Receptor 1 acts as an oncogene or tumor suppressor gene, depending on the cellular context; NUCKS1 is recognized as oncogene encoding Nuclear Casein Kinase and cyclin dependent Kinase Substrate 1 that is involved in DNA repair and promotes proliferation, invasion and migration of NSCLC (Zhao et al. 2020c); PAK4 gene codes for P21 (RAC1) Activated Kinase 4, serine/threonine protein kinase; PTK2 encodes non-receptor Protein Tyrosine Kinase 2, also known as Focal Adhesion Kinase; REV3L codes for catalytic subunit of the DNA polymerase zeta complex, involved in the chemoresistance of ESCC (Zhu et al. 2016); SMAD2 encodes the SMAD Family Member 2 protein, which can act as an oncogenic protein in the TGF-β pathway (Pefani et al. 2016); TIPRL codes for TOR Signaling Pathway Regulator that was found as metastasis suppressor in gastric cancer