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Table 2 Expression levels of miRNAs targeting i.a. TYMS mRNA in cancer

From: MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy

miRNA Level Cancers‡ References
miR-192-5p Down CRC tissues Zhao et al. (2020b)
  Down CRC cell lines (HCT116, SW480, RKO, HT29) Zheng et al. (2019b)
  Down CRC tissues (TNM stage II) Braun et al. (2008)
  Up ESCC tissues and four cell lines Li et al. (2015c)
  Down NSCLC: four cell lines (i.a. A549, H1299) Zou et al. (2019)
  Down BLCA tissues and five cell lines (i.a. T24) Ji et al. (2018)
  Down BRCA tissues, MCF-7 and MDA-MB-231 cell lines Chen et al. (2019d)
  Down HCC tissues Wang et al. (2021h)
  Down HCC tissues Lian et al. (2016)
  Down HCC tissues Ge et al. (2015)
  Down PCa: PC-3 and DU145 cell lines Sun et al. (2016)
miR-215-5p Down CRC tissues stages: III + IV vs I + II Yan et al. (2020b)
  Down CRC tissues stages: II, III, IV vs I Vychytilova et al. (2017)
  Down CRC tissues stages: IV vs III vs II vs I Chen et al. (2017c)
  Down CRC tissues: liver metastasis vs without metastasis Chen et al. (2017c)
  Down CRC tissues and cell lines (SW480, HCT116, LoVo, HT29) Chen et al. (2016)
  Down CRC tissue stages: III–IV vs I–II Chen et al. (2016)
  Down CRC tissues (stage II) Braun et al. (2008)
  Down CRC tissues Song et al. (2010)
  Up CRC CSCs Song et al. (2010)
  Up GC tissues, TNM stage III–IV vs I–II Chen et al. (2017e)
  Up GC tissues, stage III/IV vs I/II Li et al. (2016)
  Up GC tissues Deng et al. (2014b)
  Down BRCA tissues Wang et al. (2021i)
  Down BRCA tissues, stage III–IV vs I–II, three cell lines Gao et al. (2019)
  Down BRCA tissues, cell lines (i.a. MDA-MB-231) Yao et al. (2017)
  Down BRCA tissues Zhou et al. (2014a)
  Down OVCA tissues and three cell lines Ge et al. (2016)
  1. ”UP” or “down” in the level of a given miRNA: in cancerous tissues as compared to adjacent non-cancerous tissues (or to tissues of healthy individuals in cases of cervical and prostate cancers); one stage of cancer compared to another stage; cancer cell line compared to a normal epithelial cell line
  2. Cancer tissues collected from patients and cancer cell lines of various types: BLCA bladder cancer, BRCA breast cancer (various molecular subtypes including triple-negative breast cancer TNBC), CeCa cervical cancer, CRC colorectal cancer, ESCC esophageal squamous cell carcinoma, GC gastric cancer, HCC hepatocellular carcinoma, LSCC laryngeal squamous cell carcinoma, NSCLC non-small cell lung cancer (including LUAD lung adenocarcinoma SqCLC squamous cell lung carcinoma), OVCA ovarian cancer, OSCC oral squamous cell carcinoma, PCa prostate cancer, PDAC pancreatic ductal adenocarcinoma