MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy

Table 5 Major genes targeted by miR-140-3p in various types of cancer

Cancers	Targeted gene products^†	References
Cancers with down-regulation of miR-140-3p
	Acting as oncogenes or tumor promoters
CRC	BCL2, BCL9	Liu et al. (2021)
GC	BCL2	Chen et al. (2021)
ESCC	E2F3, NRIP1	Wang et al. (2021d); Chen et al. (2020d)
LUAD	TYMS	Wan et al. (2021)
Lung cancer	ATP6AP2, BRD9, JAK1	Kong et al. (2015); Huang et al. (2019a); Hu et al. (2020)
BLCA	ANXA8	Yuan et al. (2021)
HCC	GRN, VEGFA	Gao et al. (2021b); Hou et al. (2020)
OVCA	AGTR1	Qiao et al. (2021)
	Acting both as oncogenes and tumor suppressors, or unclassified
LUAD	E2F7	Wang et al. (2021f)
BRCA	TRIM28	Zhou et al. (2019)
CeCa	ELOA (TCEB3), PDZK1	Wang et al. (2021g); Wang et al. (2022a)

^†mRNAs encoding the following proteins: AGTR1 encodes the Angiotensin II Receptor Type I and is recognized as an oncogene in various cancers; ANXA8 encodes Annexin A8 that is highly expressed in some cancers; ATP6AP2 is a proto-oncogene coding for ATPase H + Transporting Accessory Protein 2 (Renin/Prorenin Receptor); BCL2 codes for anti-apoptotic protein; BCL9 codes for the coactivator involved in β-catenin mediated transcription; BRD9 encodes Bromodomain-Containing Protein 9 involved in chromatin remodeling complexes; E2F3 encodes E2F Transcription Factor 3; E2F7 is a tumor suppressor gene that encodes atypical E2F Transcription Factor 7; ELOA encodes Elongin A, also known as RNA polymerase II Transcription Elongation Factor B Subunit 3; GRN encodes Granulin Precursor that is presumably involved in tumorigenesis; JAK1 encodes Janus Kinase 1 phosphorylating a tyrosine residue; NRIP1 encodes Nuclear Receptor Interacting Protein 1 which is elevated in tumors; PDZK1 is a tumor suppressor gene encoding PDZ Domain Containing 1, scaffolding protein; TRIM28 encodes a protein that may have both oncogenic and tumor suppressor effects; VEGFA encodes Vascular Endothelial Growth Factor A that promotes angiogenesis

ISSN: 1528-3658