MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy

Table 7 Major genes targeted by miR-197-3p in various types of cancer

Cancers	Targeted gene products^†	References
Cancers with down-regulation of miR-197-3p
	Acting as oncogenes or tumor promoters
CRC	TYMS	Sun et al. (2015); Wang et al. (2019a)
GC	PRKCB	Chen et al. (2019c)
GC	CXCR6, MAPK1, MTDH	Han and Liu (2021); Xiong et al. (2015); Liao et al. (2018)
HCC	AGR2	Bi et al. (2021)
CeCa	E2F6, FOXM1	Gu et al. (2021); Hu et al. (2018b)
	Acting both as oncogenes and tumor suppressors, or unclassified
HCC	ZIK1	Ni et al. (2019)
OVCA	ABCA7	Xie et al. (2020)
Cancers with up-regulation of miR-197-3p
	Acting as tumor suppressors
NSCLC	BMF, PMAIP1 (NOXA)	Fiori et al. (2014)
LUAD	CYLD	Chen and Yang (2018)
BRCA	FBXW7, HIPK3, NLK	Ye et al. (2019); Li et al. (2021d); Tang et al. (2018)
HCC	AXIN2, NKD1, DKK2, CD82	Hu et al. (2018a); Dai et al. (2014)
	Acting both as oncogenes and tumor suppressors, or unclassified
NSCLC	CTNND1	Yang et al. (2019)

^†mRNAs encoding the following proteins: ABCA7 encodes ATP Binding Cassette Subfamily A Member 7 (Muriithi et al. 2020); AGR2 is an oncogene that encodes a protein disulphide isomerase; AXIN2, NKD1 and DKK2 function as tumor suppressors and regulators of the WNT/β-catenin pathway; BMF encodes pro-apoptotic BH3-only protein; CD82 codes for metastasis suppressor; CTNND1 encodes Catenin Delta 1 which interacts with cadherins and acts in adhesion between cells; CXCR6 encodes C-X-C Motif Chemokine Receptor 6; CYLD is a tumor suppressor gene that codes for CYLD Lysine 63 Deubiquitinase; E2F6 encodes E2F Transcription Factor 6; FBXW7 is a tumor suppressor gene encoding F-Box and WD Repeat Domain Containing 7 which targets cyclin E and c-Myc for ubiquitin-mediated degradation; FOXM1 functions as an oncogene encoding Forkhead Box M1 protein; HIPK3 codes for Homeodomain Interacting Protein Kinase 3, serine/threonine protein kinase; MAPK1 encodes Mitogen-Activated Protein Kinase 1 (p42-MAPK/ERK2); MTDH (Metadherin) acts as an oncogene and is involved in induction of TYMS (Yoo et al. 2009); NLK codes for Nemo-Like Kinase, serine/threonine protein kinase and acts as tumor suppressor in breast cancer; PMAIP1 codes for NOXA, which is a p53-induced pro-apoptotic BH3-only protein; PRKCB codes for Protein Kinase Cβ; ZIK1 encodes the Zinc Finger Protein Interacting With K Protein 1, which probably acts as a transcriptional repressor

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