Skip to main content

Table 7 Major genes targeted by miR-197-3p in various types of cancer

From: MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy

Cancers Targeted gene products References
Cancers with down-regulation of miR-197-3p
  Acting as oncogenes or tumor promoters
CRC TYMS Sun et al. (2015); Wang et al. (2019a)
GC PRKCB Chen et al. (2019c)
GC CXCR6, MAPK1, MTDH Han and Liu (2021); Xiong et al. (2015); Liao et al. (2018)
HCC AGR2 Bi et al. (2021)
CeCa E2F6, FOXM1 Gu et al. (2021); Hu et al. (2018b)
  Acting both as oncogenes and tumor suppressors, or unclassified
HCC ZIK1 Ni et al. (2019)
OVCA ABCA7 Xie et al. (2020)
Cancers with up-regulation of miR-197-3p
  Acting as tumor suppressors
NSCLC BMF, PMAIP1 (NOXA) Fiori et al. (2014)
LUAD CYLD Chen and Yang (2018)
BRCA FBXW7, HIPK3, NLK Ye et al. (2019); Li et al. (2021d); Tang et al. (2018)
HCC AXIN2, NKD1, DKK2, CD82 Hu et al. (2018a); Dai et al. (2014)
  Acting both as oncogenes and tumor suppressors, or unclassified
NSCLC CTNND1 Yang et al. (2019)
  1. mRNAs encoding the following proteins: ABCA7 encodes ATP Binding Cassette Subfamily A Member 7 (Muriithi et al. 2020); AGR2 is an oncogene that encodes a protein disulphide isomerase; AXIN2, NKD1 and DKK2 function as tumor suppressors and regulators of the WNT/β-catenin pathway; BMF encodes pro-apoptotic BH3-only protein; CD82 codes for metastasis suppressor; CTNND1 encodes Catenin Delta 1 which interacts with cadherins and acts in adhesion between cells; CXCR6 encodes C-X-C Motif Chemokine Receptor 6; CYLD is a tumor suppressor gene that codes for CYLD Lysine 63 Deubiquitinase; E2F6 encodes E2F Transcription Factor 6; FBXW7 is a tumor suppressor gene encoding F-Box and WD Repeat Domain Containing 7 which targets cyclin E and c-Myc for ubiquitin-mediated degradation; FOXM1 functions as an oncogene encoding Forkhead Box M1 protein; HIPK3 codes for Homeodomain Interacting Protein Kinase 3, serine/threonine protein kinase; MAPK1 encodes Mitogen-Activated Protein Kinase 1 (p42-MAPK/ERK2); MTDH (Metadherin) acts as an oncogene and is involved in induction of TYMS (Yoo et al. 2009); NLK codes for Nemo-Like Kinase, serine/threonine protein kinase and acts as tumor suppressor in breast cancer; PMAIP1 codes for NOXA, which is a p53-induced pro-apoptotic BH3-only protein; PRKCB codes for Protein Kinase Cβ; ZIK1 encodes the Zinc Finger Protein Interacting With K Protein 1, which probably acts as a transcriptional repressor