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Fig. 3 | Molecular Medicine

Fig. 3

From: Activation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis

Fig. 3

Stimulation of sigma-1 receptor alleviated post-infarct heart failure-induced ventricular remodeling. A S1R stimulation reduced infarct area; B S1R stimulation decreased collagen deposition in the peri-infarction zone, evidenced by the Sirius red dyeing; C Western blot results showed that stimulation of S1R improved apoptosis and fibrosis. N = 3 for quantified analysis; D S1R stimulation reduced cardiomyocyte apoptosis in the peri-infarct region, which was detected by Terminal-deoxynucleotidyl Transferase-Mediated Nick-End Labeling (TUNEL) assay. *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.001

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Molecular Medicine

ISSN: 1528-3658