Fig. 5From: Activation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesisTransfection of Ad-S1R promoted angiogenesis of HUVECs. A Western blot results showed that transfection of AAV-S1R upregulated the sigma-1 receptor expression. N = 3 for quantified analysis; B Ad-S1R transfected enhanced proliferation of HUVECs, confirmed by CCK-8 experiment; C Ad-S1R transfected HUVECs accelerated tube formation. *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.001Back to article page