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Fig. 6 | Molecular Medicine

Fig. 6

From: Activation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis

Fig. 6

Transfection of Ad-S1R promoted angiogenesis of HUVECs through JAK2/STAT3 signaling pathway. A Western blot results showed that AG490 inhibited JAK2/STAT3 signaling pathway activation. N = 3 for quantified analysis; B In vitro incubation of JAK2/STAT3 inhibitor 50 μM AG490 decreased tube formation; C AG490 counteracted the pro-proliferative effect of Ad-S1R transfection on HUVECs; *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.001

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Molecular Medicine

ISSN: 1528-3658